Feasible regions of operating parameters

This tool calculates the boundaries of the feasible Unified Design operating parameter regions in a batch column or in a classical 4-zone SMB process.

The results are valid for binary separation with linear isotherms or competitive Langmuir isotherms under ideal conditions. In the SMB, it is assumed that the adsorbent and the eluent are regenerated before recycling between zones I and IV.

Choose isotherm type
Fresh feed
\( c_1^{FF} \)
\( c_2^{FF} \)
Isotherm parameters
\( q_\text{s1} \)
\( b_1 \)
\( q_\text{s2} \)
\( b_2 \)
\( H_1 \)
\( H_2 \)
Packing
\( \epsilon_\text{bed} \)
Boundaries of the feasible regions
\( PU_1 \)
\( PU_2 \)
\( \text{max} s^\text{FF} \)
\( n_\text{points} \)
Operating point
\( s^\text{FF} \)
\( s_\text{cut} \)
Aspect ratio: square | flat | very flat
Operating point \( s_\text{cut} \) = \( s^\text{FF} \) = \( S_\text{cut} \) =
Purity \( PU_1 \) = \( PU_2 \) =
Yield \( Y_1 \) = \( Y_2 \) =
Productivity \( PR_1 \) = \( PR_2 \) =
Eluent consumption \( EC_1 \) = \( EC_2 \) =
Further reading:
1. Sainio, T., Unified Design of Chromatographic Separation Processes: Partial Separations and Waste Fractions, Chem. Eng. Sci. (2021), 116457. (open access)
2. Sainio, T., Unified design of chromatographic processes with timed events: ternary separations, Chem. Eng. Sci., 152(2016), 547−567.
3. Siitonen, J., Sainio, T., Unified design of chromatographic separation processes, Chem. Eng. Sci., 122(2015), 436-451.
4. Siitonen, J., Sainio, T., Explicit equations for the height and position of the first component shock for binary mixtures with competitive Langmuir isotherms under ideal conditions, J. Chromatogr. A, 1218(2011), 6379-6387
5. Siitonen, J., Sainio, T., Rajendran, A., Design of batch chromatography for separation of binary mixtures under reduced purity requirements, J. Chromatogr. A, 1286(2013), 55-68
6. Sainio, T., Kaspereit, M., Analysis of steady state recycling chromatography using equilibrium theory, Sep. Purif. Technol., 66(2009), pp. 9-18
7. Kaspereit, M., Sainio, T., Simplified design of steady-state recycling chromatography under ideal and nonideal conditions, Chem. Eng. Sci., 66 (2011), pp. 5428-5438
8. G. Storti, M. Mazzotti, M. Morbidelli, S. Carrà, Robust design of binary counter current adsorption separation processes, AIChE J., 39 (1993), pp. 471-492

Disclamer: No liability is assumed for correctness or completeness of data generated with the tools available on this website.

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